Dr Lucio Marcello
Dr Lucio Marcello
Senior Bioinformatician
With expertise in the fields on parasitology, human genetics, population biology and environmental DNA (eDNA) monitoring, I am passionate about collaborative research, and keen to further develop and integrate bioinformatics tools informing applied research in the Scottish rural and environmental sectors. I also have experience as a bioinformatics consultant for companies, building pipelines to automate bespoke analytical workflows.
Research interest:
- Development of bioinformatics tools and workflows for environmental DNA datasets
- Mapping and extending the application of k-mer analysis applied to NGS data (microbial classification)
- Development / adaptation of genomic applications for serverless cloud computing
- Investigating the spread of antimicrobial resistance (AMR) in farm systems
- Reconstructing and validating mitochondrial phylogenies on incomplete datasets using imputation
Research project highlights:
- Healthy soils: microbiome analysis of soil collected in grasslands with different grass composition, and its relationship to carbon and nitrogen cycling metrics (in collaboration with the James Hutton Institute)
- AMR in farm systems: measuring the spread of AMR from livestock farms to the surrounding environment (in collaboration with SRUC)
Past projects
- Cloudbutton (EU project): development of a serverless variant calling pipeline for adoption in cloud computing, in collaboration with URV cloud computing department (Spain)
- AMBER (EU project): assessment of the impact of hydropower on freshwater ecology, by eDNA and other methods, with particular reference to the Upper Ness catchment.
Publications:
Marcello L, Chafin T, Ribeca P Genomics Use Case. In: García P, París G, Palmero R, Lopez L, Velin T, Jorge E, Alexandrov T, Ribeca P, Segarra C, Shillaker S, Li G, Sartakov V, Sánchez M CloudButton Serverless Data Analytics Platform: D2.3 Reference Implementation of Architectural Building Blocks, EU Report, 2022, https://cloudbutton.eu/docs/deliverables/CloudButton_D2.3_Public.pdf
Belletti B, Garcia de Leaniz C, Jones J, Marcello L, Zalewski M More than one million barriers fragment Europe’s rivers, Nature; 2020
Marcello L et al. Case Study 4: Quoich Dam, Upper River Garry (in Report of case studies demonstrating the effects of barrier removal, mitigation and installation), AMBER project EU report, 2020, May
Jones J, Börger L, Tummers J, Jones P, Lucas M, Kerr J, Kemp P, Bizzi S, Consuegra S, Marcello L, Vowles A, Belletti B, Verspoor E, Van de Bund W, Gough P, Garcia de Leaniz, C. A comprehensive assessment of stream fragmentation in Great Britain. Science of The Total Environment. 2019; 673:756–762.